MTRAM Translational Technologies (TR): Translational genomics

This course is part of a three-quarter series (A, B, C) and complements courses offered as part of a master's in Translational Research and Applied Medicine (M-TRAM). (A: Fall: Biomarker Discovery; B: Winter: Translational Proteomics, C: Spring: Translational Genomics). In this quarter, students will learn the fundamentals of translational genomics, with the emphasis on single cell genomics. The topics will include library preparation, understanding the fundamental principles of the sequencing methods, types of single cell sequencing assays available and data analysis. The emphasis will be on how these methods are used to delineate immunologic cell types, their interactions with other cells in the local microenvironment and determining differential gene expression patterns and signatures. Lectures and labs will demonstrate how single cell immunogenomics are being applied to immunotherapy development. At its core, this course teaches the principles of genomics-based methosis and appreciating how the nature and type of data impact the analysis approach. This course is necessary to provide students with the broader skillset to conduct their MTRAM capstone project and adapt and grow in the field as technologies change. MTRAM students are required to take 3 units (lecture + lab). 1 unit course is lectures only (no lab).