Apico-basolateral Epithelial Cell Polarity

Cells must polarize, localizing unique macromolecules along distinct axes, to function correctly. This lecture/lab mini-course will provide students with a broad overview of cell polarity, using recent literature to guide understanding of the shared and divergent mechanisms underlying polarity establishment in different tissues and organisms. Additionally, students will engage in hands-on research using C. elegans and a large particle flow cytometer (BIOSORTER) to perform high throughput forward genetic screens to discover novel pathways involved in epithelial polarity establishment. This course is geared toward STEM graduate students, postdocs, and advanced undergraduates interested in topics and applications in cell and developmental biology.