Bioengineering Innate Immunity

The innate immune system provides the first line of defense against infections and cancers. Dysregulated innate immunity underlies neoplastic, autoimmune and neurodegenerative diseases. Many cell types (neutrophils, macrophages, NK & T cells, epithelial and endothelial cells) deploy and/or are modulated by innate immune effectors, e.g. host defense peptides. From primary literature, we discuss the breadth, structures, and functions of cellular and molecular innate immune effectors, their relation to disease, and how bioengineering these systems can benefit human health. Appropriate for grads and undergrads with knowledge of biochemistry, molecular/cell biology, biophysics, and/or bioengineering.