Single Cell Immunogenomics

Preference is for graduate students and undergraduates with background in biology and genetics. The emphasis of the course will be on learning the essential principles of single cell genomics as applied to research questions in immunology. The topics will include understanding the fundamental principles of the technology, experimental methods, types of single cell sequencing assays available and data analysis. The emphasis will be on how these methods are used to delineate immunologic cell types, their interactions with other cells in the local microenvironment and determining differential gene expression patterns and signatures. Specialized topics will include the analysis of single cell T-cell and B-cell receptor characteristics as well as joining antibody staining information at single cell resolution. Guest speakers will include thought leaders in the field who are demonstrating how single cell immunogenomics are being applied to immunotherapy development. Enrollment is limited.